Publications & Posters
Development of ArgTag for Scalable Solid-Phase Synthesis of Aggregating Peptides
Vincent Freiburghaus, Aliénor Jeandin, Łukasz Frankiewicz, Jie Yang, and Nina Hartrampf University of Zurich
The "ArgTag" method uses a simplified six-arginine tag to prevent difficult peptide chains from clumping together during solid-phase peptide synthesis (SPPS).
Developed by researchers at the University of Zurich utilizing the PeptiPilot and published in ACS Chemical Biology, this technique helps chemists make challenging, aggregation-prone peptide sequences with much higher purity and yield.
Flow – SPPS towards greener and more efficient peptide manufacturing
Oliver Kracker & Eike-Fabian Sachs
Corden Pharma International GmbH
Corden Pharma used the PeptiPilot to synthesize a 39 amino acid linear peptide - GLP-1 agonist Exenatide. Total solvent use compared to conventional batch SPPS methods was reduced 35 - 61% while piperidine utilization in deprotection was reduced ~50%.