The next generation of synthesis instruments for oligonucleotide process development and manufacturing

OligoNavigator

®

OligoNavigator represents a new generation of fully automated solid-phase oligonucleotide synthesis instruments using flowthrough column technology.

OligoNavigator introduces extended monitoring capabilities, the ability to perform synthesis at elevated temperatures, and unmatched flexibility and synthesis control using software that has been purpose-built for this application.

A flexible and fully automated oligonucleotide synthesizer

OligoNavigator is a compact, pump-driven instrument for process development and small-scale synthesis of oligonucleotides in the scale 0.1-12 mmol. The synthesis is performed in the column which is compatible with various types of polymer supports. Once the synthesis method has been developed and optimized, it can be seamlessly transferred to a larger-scale OligoNavigator Plus or OligoNavigator Pro instrument using PeptiSoft synthesis software.

The instrument is designed for research and process development of oligonucleotides, designed to meet the needs of various synthesis chemistries.

State-of-the-art flexibility of individual cycles in synthesis methods, backbone chemistry, use of custom made monomers including monomers ready for bioconjugation.
Cost-efficient and high-quality synthesis with high purity, yield and reproducibility.
Five column positions and up to 12 amidite monomer inlets.
Easy scale-up due to linear flow rates and washing based on column volumes.
In-line monitoring with conductivity and diode-array detectors (including the UV/VIS spectrum).
A heater for synthesis at elevated temperatures and temperature control.
Works with PeptiSoft synthesis management software which is designed according to 21 CFR Part 11 and GAMP5.
Installation and Operational Qualification (IQ/OQ) documentation is available.

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Overview PeptiPilo

Key New Features

Key new features of the OligoNavigator

Software built from scratch for GMP synthesis of oligonucleotides with process development and scalability in mind. We have developed a synthesis matrix that makes it easy to set individual parameters of any synthesis step in any synthesis cycle. This allows for improved synthesis control. The software is also much easier to operate than others on the market and brings a modern, user-friendly interface to the field of oligonucleotide synthesis.

A built-in heater allows for heating up to 50°C in any individual synthesis step. Performing synthesis steps at elevated temperatures can be of strong interest to increase the speed of various steps of a cycle such as the activation or coupling step. It also makes it possible to control the temperature of the entire cycle to keep it constant. (Cooling options are available on the OligoNavigator Pro).

Higher purities and yields have been achieved than for industry standard synthesis instruments.

Addition of new real-time monitoring features such as conductivity, complete-UV scans, and Near Infrared NIR (OligoNavigator Pro only) leads to improved monitoring, automation, and synthesis control. PeptiSystems is currently working on further monitoring improvements where the software itself will be able to determine when any step in the synthesis cycle is complete and automatically move on to the next step, without any manual estimations from the operator.

Easier scale-up and transfer of optimized synthesis method. The same software is used during large-scale synthesis as in pilot-scale synthesis.

Specifications PeptiPilot

Specifications for OligoNavigator