A game changer in large-scale peptide manufacturing

PeptiPro

PeptiPro is a fully automated large-scale peptide synthesizer and covers a range from 50 mmol up to 5 mol per batch. Each design is customized depending on the customers specifications and is based on verified components from established and well known suppliers in the industry.

 

The broad scale covered by the PeptiPro instrument enables production of hundreds of kilograms or even metric tons of peptides every year. PeptiPro will completely transform your peptide manufacturing, factory utilization and productivity. 

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PeptiPro is a fully automated solid-phase peptide synthesis instrument using flowthrough column technology. It is a compact, pump-driven system for large-scale synthesis in the scale 10 mmol - 5 mol, and supports production of both GMP and non-GMP peptides. The synthesis is performed in the column on the resin of your choice, starting from 1% cross linking to low/non-swellable polymer supports. The synthesis method is first developed and optimized on a PeptiPilot or PeptiPilot Plus instrument prior to transferring and manufacturing on a PeptiPro. 

The instrument is designed for synthesis process development and large-scale production of peptides. It is constructed to meet the needs of various synthesis chemistries. Some key characteristics of the system are: 

 

  • State-of-the-art flexibility in synthesis methods, chemistry and scale.

  • Use the same reagents, resins, solvents and reagents, as you normally would in SPPS.

  • Cost-efficient and high-quality synthesis with high purity, yield and reproducibility.

  • Easy scale-up by using linear flowrates and fixed column volumes for washing. 

  • Two column positions for sequential, non-stop synthesis, and up to 27 amino acid inlets (customer to specify). 

  • Continuous real-time monitoring with a diode-array detector (including full UV spectrum) and conductivity sensors.

  • A built-in heater allows for synthesis at elevated temperatures by heating the liquid.  

  • Works with PeptiSoft synthesis management software which is designed according to 21 CFR Part 11 and GAMP5.

  • Swelling and shrinking of resin handled by optimised template methods for each column size.

  • Installation and Operational Qualification (IQ/OQ) documentation is available.

  • A mixer allows for pre-activation of amino acids prior to coupling. 

  • Extremely accurate pump system that adds the correct amount of liquid to the system. 

One PeptiPro can replace up to 5 traditional batch reactor instruments and has a payback time of 3-12 months depending on how often it is used and the scale of production.  

A new generation of large-scale peptide manufacturing 

 

Benefits compared to batch reactor technology

 
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50-90% reduction in synthesis time and improvement in productivity by up to 10x. Complete the synthesis of a peptide in 1-3 days instead of 3-4 weeks. Leads to increase in productivity, improved factory capacity, cost decrease and improved lead time to customers.

Improved product purity and yield (~15%). Obtain more product at a lower production cost!

Save costs by reducing solvent consumption by 50-70%. With a cost of around 5 USD/Liter, this leads to savings of millions of USD per year. 

Continuous real-time monitoring increases synthesis control and allows automation for each synthesis step. Manual sampling is no longer needed.

Easier scale-up saves further on time and costs. Perform process development in pilot scale and use exact same optimized synthesis parameters for large-scale synthesis (up to 5 mol).

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Improved carbon and environmental footprint. Reduction in solvent consumption results in up to 50% reduction of CO2 emissions, which can lead up to a reduction of 100 tons of CO2 emitted per year per instrument. 

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Specifications for PeptiPro

 

Related Documents

 

Whitepapers, brochures and other related documents will soon be made available for download here.