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A game changer in process development and manufacturing of peptides

PeptiPilot

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Optimize your process development, greatly reducing the time and resources spent. Easily scale-up the synthesis using the same synthesis method based on linear flowrates and optimized parameter settings.

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PeptiPilot is transforming the way peptides are produced, greatly saving costs, resources and time spent compared to traditional batch reactor technology.

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A flexible and fully automated peptide synthesizer

PeptiPilot is a fully automated solid-phase peptide synthesis instrument using flowthrough column technology. It is a compact, pump-driven system for small-scale synthesis in the scale 0.1-12 mmol. The synthesis is performed in the column on the resin of your choice, starting from 1% cross linking to low/non-swellable polymer supports. The method developed can then be transferred to a larger-scale PeptiPilot Plus or PeptiPro instrument. 

 

PeptiPilot is designed for synthesis process development and small-scale production of peptides. It is constructed to meet the needs of various synthesis chemistries. Some key characteristics of the system are: 

 

  • State-of-the-art flexibility of individual cycles in synthesis methods, chemistry and scale.

  • Use the same reagents, resins, solvents and reagents, as you normally would in SPPS.

  • Cost-efficient and high-quality synthesis with high purity, yield and reproducibility.

  • Easy scale-up by using linear flowrates and fixed column volumes for washing. 

  • Five column positions and up to 27 amino acid containers.

  • Continuous real-time monitoring with a diode-array detector (including full UV spectrum) and conductivity sensors.

  • A built-in heater allows for synthesis at elevated temperatures up to 50°C by heating the liquid.  

  • Works with PeptiSoft synthesis management software which is designed according to 21 CFR Part 11 and GAMP5.

  • Swelling and shrinking of resin handled by optimised template methods for each column size.

  • Installation and Operational Qualification (IQ/OQ) documentation is available.

  • A separate mixer allowing amino acid pre-activation prior to coupling. 

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Overview PeptiPilo

Benefits compared to batch reactor technology

Benefits compard to batch reacto
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50-90% reduction in synthesis time and improvement in productivity by up to 10x. Complete the synthesis of a peptide in 1-3 days instead of 3-4 weeks. Leads to increase in productivity, improved factory capacity, cost decrease and improved lead time to customers.

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Improved product purity and yield (~15%). Obtain more product at a lower production cost!

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Save costs by reducing solvent consumption by 50-70%. With a cost of around 5 USD/Liter, this leads to savings of millions of USD per year. 

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Continuous real-time monitoring increases synthesis control and allows automation for each synthesis step. Manual sampling is no longer needed.

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Easier scale-up saves further on time and costs. Perform process development in pilot scale and use exact same optimized synthesis parameters for large-scale synthesis (up to 5 mol).

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Improved carbon and environmental footprint. Reduction in solvent consumption results in up to 50% reduction of CO2 emissions, which can lead up to a reduction of 100 tons of CO2 emitted per year per instrument.

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Specifications PeptiPilot

Specifications for PeptiPilot

Related Documents Peptipilot

Related Documents

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