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A game changer in process development and manufacturing of peptides
PeptiPilot
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Optimize your process development, greatly reducing the time and resources spent. Easily scale-up the synthesis using the same synthesis method based on linear flowrates and optimized parameter settings.
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PeptiPilot is transforming the way peptides are produced, greatly saving costs, resources and time spent compared to traditional batch reactor technology.
A flexible and fully automated peptide synthesizer
PeptiPilot is a fully automated solid-phase peptide synthesis instrument using flowthrough column technology. It is a compact, pump-driven system for small-scale synthesis in the scale 0.1-12 mmol. The synthesis is performed in the column on the resin of your choice, starting from 1% cross linking to low/non-swellable polymer supports. The method developed can then be transferred to a larger-scale PeptiPilot Plus or PeptiPro instrument.
PeptiPilot is designed for synthesis process development and small-scale production of peptides. It is constructed to meet the needs of various synthesis chemistries. Some key characteristics of the system are:
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State-of-the-art flexibility of individual cycles in synthesis methods, chemistry and scale.
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Use the same reagents, resins, solvents and reagents, as you normally would in SPPS.
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Cost-efficient and high-quality synthesis with high purity, yield and reproducibility.
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Easy scale-up by using linear flowrates and fixed column volumes for washing.
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Five column positions and up to 27 amino acid containers.
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Continuous real-time monitoring with a diode-array detector (including full UV spectrum) and conductivity sensors.
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A built-in heater allows for synthesis at elevated temperatures up to 50°C by heating the liquid.
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Works with PeptiSoft synthesis management software which is designed according to 21 CFR Part 11 and GAMP5.
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Swelling and shrinking of resin handled by optimised template methods for each column size.
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Installation and Operational Qualification (IQ/OQ) documentation is available.
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A separate mixer allowing amino acid pre-activation prior to coupling.
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Benefits compared to batch reactor technology
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50-90% reduction in synthesis time and improvement in productivity by up to 10x. Complete the synthesis of a peptide in 1-3 days instead of 3-4 weeks. Leads to increase in productivity, improved factory capacity, cost decrease and improved lead time to customers.
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Improved product purity and yield (~15%). Obtain more product at a lower production cost!
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Save costs by reducing solvent consumption by 50-70%. With a cost of around 5 USD/Liter, this leads to savings of millions of USD per year.
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Continuous real-time monitoring increases synthesis control and allows automation for each synthesis step. Manual sampling is no longer needed.
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Easier scale-up saves further on time and costs. Perform process development in pilot scale and use exact same optimized synthesis parameters for large-scale synthesis (up to 5 mol).
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Improved carbon and environmental footprint. Reduction in solvent consumption results in up to 50% reduction of CO2 emissions, which can lead up to a reduction of 100 tons of CO2 emitted per year per instrument.
