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A game changer in process development and manufacturing of peptides

PeptiPilot Plus

Optimize your process development, greatly reducing the time and resources spent. Easily scale-up the synthesis using the same synthesis method based on linear flowrates and optimized parameter settings.

PeptiPilot Plus is transforming the way peptides are produced, greatly saving costs, resources and time spent compared to traditional batch reactor technology.

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A flexible and fully automated peptide synthesizer

PeptiPilot Plus is a fully automated solid-phase peptide synthesis instrument using flowthrough column technology. It is a compact, pump-driven system for small-scale synthesis in the scale 4-40 mmol. The synthesis is performed in the column on the resin of your choice, starting from 1% cross linking to low/non-swellable polymer supports. The method developed can then be transferred to a larger-scale PeptiPro instrument for commercial manufacturing of for example therapeutic peptides. 


PeptiPilot Plus is designed for synthesis process development and medium-scale production of peptides such as pre-clinical material. It is constructed to meet the needs of various synthesis chemistries. Some key characteristics of the system are: 


  • State-of-the-art flexibility of individual cycles in synthesis methods, chemistry and scale.

  • Use the same reagents, resins, solvents and reagents, as you normally would in SPPS.

  • Cost-efficient and high-quality synthesis with high purity, yield and reproducibility.

  • Easy scale-up by using linear flowrates and fixed column volumes for washing. 

  • Five column positions and up to 27 amino acid containers.

  • Continuous real-time monitoring with a diode-array detector (including full UV spectrum) and conductivity sensors.

  • A built-in heater allows for synthesis at elevated temperatures by heating the liquid.  

  • Works with PeptiSoft synthesis management software which is designed according to 21 CFR Part 11 and GAMP5.

  • Swelling and shrinking of resin handled by optimised template methods for each column size.

  • Installation and Operational Qualification (IQ/OQ) documentation is available.

  • A mixer allows for pre-activation of amino acids prior to coupling. 

Overview PeptiPilo
Benefits compard to batch reacto

Benefits compared to batch reactor technology

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50-90% reduction in synthesis time and improvement in productivity by up to 10x. Complete the synthesis of a peptide in 1-3 days instead of 3-4 weeks. Leads to increase in productivity, improved factory capacity, cost decrease and improved lead time to customers.

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Improved product purity and yield (~15%). Obtain more product at a lower production cost!

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Save costs by reducing solvent consumption by 50-70%. With a cost of around 5 USD/Liter, this leads to savings of millions of USD per year. 

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Continuous real-time monitoring increases synthesis control and allows automation for each synthesis step. Manual sampling is no longer needed.

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Easier scale-up saves further on time and costs. Perform process development in pilot scale and use exact same optimized synthesis parameters for large-scale synthesis (up to 5 mol).

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Improved carbon and environmental footprint. Reduction in solvent consumption results in up to 50% reduction of CO2 emissions, which can lead up to a reduction of 100 tons of CO2 emitted per year per instrument. 

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Specifications PeptiPilot

Specifications for PeptiPilot Plus

Related Documents Peptipilot

Related Documents


Whitepapers, brochures and other related documents will soon be made available for download here. 

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