PeptiPilot Plus is a fully automated solid-phase peptide synthesis instrument using flowthrough column technology. It is a compact, pump-driven system for small-scale synthesis in the scale 4-40 mmol. The synthesis is performed in the column on the resin of your choice, starting from 1% cross linking to low/non-swellable polymer supports. The method developed can then be transferred to a larger-scale PeptiPro instrument for commercial manufacturing of for example therapeutic peptides. 

 

PeptiPilot Plus is designed for synthesis process development and medium-scale production of peptides such as pre-clinical material. It is constructed to meet the needs of various synthesis chemistries. Some key characteristics of the system are: 

 

• State-of-the-art flexibility of individual cycles in synthesis methods, chemistry and scale.

• Use the same reagents, resins, solvents and reagents, as you normally would in SPPS.

• Cost-efficient and high-quality synthesis with high purity, yield and reproducibility.

• Easy scale-up by using linear flowrates and fixed column volumes for washing. 

• Five column positions and up to 27 amino acid containers.

• Continuous real-time monitoring with a diode-array detector (including full UV spectrum) and conductivity sensors.

• A built-in heater allows for synthesis at elevated temperatures by heating the liquid.  

• Works with PeptiSoft synthesis management software which is designed according to 21 CFR Part 11 and GAMP5.

• Swelling and shrinking of resin handled by optimised template methods for each column size.

• Installation and Operational Qualification (IQ/OQ) documentation is available.

• A mixer allows for pre-activation of amino acids prior to coupling. 

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