Improve Your Process Economy and Control

For Peptide and Oligonucleotide Manufacturing

 
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PeptiSystems Products

PeptiSystems offers a new generation of instruments for solid-phase synthesis production of peptide and oligonucleotide therapeutics. Our instruments are used within the biopharmaceutical and biotech industry for process development and large-scale GMP and non-GMP manufacturing based on flowthrough column technology.

 

Chemistry first - our instruments are designed from a chemistry perspective to give maximum flexibility and control without compromise. 

Research and Laboratory   |   Process Development    |    Large-scale production   |    Clinical trials 

Our Technology

 

Our patent-pending technology based on continuous flow is changing the way peptide and oligonucleotide therapeutics are manufactured. 

Faster

Fully automated instruments with as little as 1-3 hour cycle time resulting in up to 10x faster manufacturing compared to using batch reactor technology. Flexible process development using pilot-scale instruments makes it easy to optimize the synthesis method and smoothly transfer for large-scale manufacturing. 

Easy Scale-up

Unique linear scale-up technology uses the same synthesis parameters from process development in large-scale manufacturing. This means that it takes the same amount of time to synthesize in small-scale as in large-scale. Supports up to 5 mol.

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Improved Control

Specifically designed for peptide and oligonucleotide synthesis. Real-time monitoring and graphical presentation of key parameters provides continuous detailed insight into synthesis progress and sends alarms/messages if needed.

 

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PeptiPilot and PeptiPilot Plus

R&D  |  Process Development  |  Pre-clinical and clinical trials

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  • Scale: 0.1-12 mmol (PeptiPilot) and 4-40 mmol (PeptiPilot Plus).

  • Supports using industry standard resins, reagents and solvents.

  • 50-90% reduction of synthesis time from weeks to 1-3 days. 

  • Increase yield and purity by up to 15%. 

  • Reduce solvent consumption by up to 50%.

  • Automates the synthesis, reducing cycle time to 1-3h. 

  • Continuous real-time monitoring tracks the progress in each synthesis step. 

PeptiPro

Large-scale synthesis   |   GMP Commercial Production   |   Clinical Trials

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  • Scale: customizable from 50 mmol up to 5 mol per batch. 

  • Fully automated for large-scale/commercial manufacturing.

  • Smooth transfer of synthesis method from PeptiPilot and PeptiPilot Plus. 

  • Continuous real-time monitoring tracks the progress in each synthesis step. 

  • Consistently high reproducibility and same short synthesis time as with PeptiPilot and PeptiPilot Plus.​

OligoNavigator and OligoNavigator Plus

R&D  |  Process Development  |  Clinical trials  |  Pre-clinical material

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  • Scale: 0.1-8 mmol (OligoNavigator) and 4-30 mmol (Plus).

  • Up to 12 amidite building block inlets.

  • Flexible and easy-to-use software matrix for setting parameters for synthesis. 

  • In-line heater for heating of various synthesis steps up to 50°C.

  • Diode array and conductivity monitors.

  • Synthesis method is easily transferred to OligoNavigator Pro.

OligoNavigator Pro

Large-scale synthesis  |   GMP Commercial Production    |   Clinical trials  

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  • Scale: customizable from 50 mmol up to 5 mol per batch. 

  • Fully automated for large-scale/commercial manufacturing.

  • Smooth transfer of synthesis method from OligoNavigator and Plus instruments. 

  • Consistently high reproducibility and same short synthesis time as with OligoNavigator and OligoNavigator Plus. 

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Uppsala Business Park, Sweden